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KMID : 1130620110070010043
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Journal of Clinical Neurology
2011 Volume.7 No. 1 p.43 ~ p.46
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Seropositive Myasthenia Gravis Associated with Small-Cell Lung Carcinoma
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Ohira Masayuki
Jeong Du-Shin
Oh Shin J
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Abstract
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Background: Lambert-Eaton myasthenic syndrome is well known to be a classical paraneoplastic syndrome of small cell lung carcinoma (SCLC). Three cases of seronegative myasthenia gravis (MG) and SCLC were previously reported.
Case Report: A 65-year-old man developed a severe progressive respiratory failure with clinical features of MG. Tests showed a decremental response in the repetitive nerve stimulation test, abnormal single-fiber electromyography, and positive acetylcholine receptor antibody. SCLC was confirmed by the lung biopsy.
Conclusions: This case represents the first case of seropositive MG and SCLC.
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KEYWORD
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acetylcholine receptor antibody, myasthenia gravis, small cell lung cancer
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